Our Evolving Understanding of ME/CFS
نویسندگان
چکیده
The potential benefits of the scientific insights gleaned from years treating ME/CFS for emerging symptoms COVID-19, and in particular Longhaul- or Longhauler-COVID-19 are discussed this opinion article. Longhaul COVID-19 is current name being given to long-term sequelae (symptoms lasting beyond 6 weeks) SARS-CoV-2 infection. Multiple case definitions exist, but post-exertional malaise (PEM) currently as ‘hallmark’ symptom. inability identify a unique trigger ME/CFS, well specific, diagnostic laboratory test, led many physicians conclude that illness was psychosomatic non-existent. However, recent research US UK, championed by patient organizations their use internet social media, suggest underlying pathophysiologies, e.g., oxidative stress mitochondrial dysfunction. similarity overlap us similar pathological processes. We put forward unifying hypothesis explains precipitating events such viral triggers other documented exposures: For symptoms, should be described Post Active Phase Infection Syndromes (PAPIS). further propose biochemical pathways pathophysiological processes regardless initiating trigger. Exploration yield effective therapies these conditions others may exhibit symptoms. patients have suffered far too long. COVD-19 not subject fate. caution failure meet now combined challenges will impose serious socioeconomic clinical consequences patients, families society whole.
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ژورنال
عنوان ژورنال: Medicina
سال: 2021
ISSN: ['1728-452X', '2518-1009']
DOI: https://doi.org/10.3390/medicina57030200